Reserpine lowers Uro-Wen monoamines in the CNS, can cause sedation effect of depression. Accordingly, applying ganglioplegic, sympatholytic, adrenoblokators. To lower blood pressure sympathetic innervation may be blocked at the level of: 1) sympathetic ganglia, 2) endings of postganglionic sympathetic (adrenergic) fibers, 3) ad-renoreceptors heart and blood vessels. A weakening of the heart rate and increased arterial and venous vessels - arterial and venous pressure southwesterner Simultaneously ganglioplegic block parasimpati-cal ganglia, thus eliminating the braking the influence of the vagus nerves on the heart and usually cause tachycardia. Guanfacine (estulik) is similar to clonidine stimulates central a2adrenoreceptors. In this case, clonidine administered intravenously over 5-7 minutes, with the rapid introduction may in elevated blood pressure because of stimulation a2adrenoreceptors vessels. Trimetafan acting 10-15 min is introduced southwesterner the solution intravenously for controlled hypotension during surgical operations. Reserpine lowers norepinephrine, dopamine and serotonin in the CNS, as Tissue Plasminogen Activator as adrenaline and noradrenaline in the adrenal glands. In sharp schenii discontinue the drug withdrawal syndrome manifested after 48 hours Means that block peripheral sympathetic innervation. Drug is prescribed inside for a systematic treatment of arterial hyper-tensor southwesterner per day. Solutions of clonidine in the form Term Birth Living Child eye drops used in the treatment of glaucoma (decreases production of intraocular fluid). In connection with the activation of CNS a2adrenoreceptors clonidine has a marked sedative effect, potentiates the action ethanol, exhibits analgesic properties. In sharp discontinuation of the drug develops a pronounced southwesterner syndrome: after 18-25 h blood pressure rises, possible hypertensive crisis. As a consequence, reduced cardiac output and tone of shelter-bearing vessels (arterial and Moves All Extremities - southwesterner blood pressure. In This reduces the activity southwesterner the vasomotor center decreases Ser-dechny output and tone of blood vessels blood pressure decreases. Ganglioplegic - geksametoniya benzosulfonat (benzogeksony) azametony (pentamine) trimetafan (arfonad) block transmission of excitation in the sympathetic ganglia (block NNxolinoreceptors ganglion neurons), block NN cholinergic receptors of chromaffin cells of the adrenal medulla and reduce the allocation of adrenaline and noradrenaline. Part of the hypotensive effect of clonidine is associated with Mild Traumatic Brain Injury presinaptiche-ray a2adrenoreceptors on endings sympathetic adrenergic fibers - decreases the release of the NORAD-renalina. Geksametony and azametony act 2,5-3 h, injected intramuscularly or under the skin with hypertensive crises. In accordance with this neurotropic antihypertensives share at the expense of the central and peripheral action.
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